 | | Fox Mulder (David Duchovny) & Dana Scully (Gillian Anderson) - The X Files | |  | | Jack Shephard (Matthew Fox) & Kate Austen (Evangeline Lilly) - Lost | |  | | Michael Samuelle (Roy Dupuis) & Nikita (Peta Wilson) - La Femme Nikita | |  | | Ray Barnett (Shane West) & Neela Rasgotra (Parminder Nagra) - ER | |  | | Gil Grissom (William Petersen) & Sara Sidle (Jorja Fox) - CSI | |  | | Sawyer (Josh Holloway) & Kate Austen (Evangeline Lilly) - Lost | |
 | | Michael Scofield (Wentworth Miller) & Sara Tancredi (Sarah Wayne Callies) - Prison Break | |  | | George O'Malley (T.R. Knight) & Izzie Stevens (Katherine Heigl) - Grey's Anatomy | |  | | Luka Kovac (Goran Visnjic) & Abby Lockhart (Maura Tierney) - ER | |  | | Danny Messer (Carmine Giovinazzo) & Lindsay Monroe (Anna Belknap) - CSI:NY | |  | | Eric Delko (Adam Rodriguez) & Calleigh Duquesne (Emily Proctor) - CSI:Miami | |  | | Temperance 'Bones' Brennan (Emily Deschanel) & Seeley Booth (David Boreanaz) - Bones | |
 | | Jin-Soo Kwon (Daniel Dae Kim) & Sun-Hwa Kwon (Yunjin Kim) - Lost | |  | | Christian Troy (Julian McMahon) & Kimber Henry (Kelly Carlson) - Nip/Tuck | |  | | Izzie Stevens (Katherine Heigl) & Alex Karev (Justin Chambers) - Grey's Anatomy | |  | | Derek Shepherd (Patrick Dempsey) & Meredith Grey (Ellen Pompeo) - Grey's Anatomy | |  | | Sydney Bristow (Jennifer Garner) & Michael Vaughn (Michael Vartan) - Alias | |  | | Carol Hathaway (Julianna Margulies) & Doug Ross (George Clooney) - ER | |
 | | Brian Kinney (Gale Harold) & Justin Taylor (Randy Harrison) - Queer As Folk | |  | | Harmon 'Harm' Rabb, Jr. & Sarah 'Mac' MacKenzie (JAG) | |  | | Bette Porter (Jennifer Beals) & Tina Kennard (Laurel Holloman) - The L Word | |  | | Greg House (Hugh Laurie) & Lisa Cuddy (Lisa Edelstein) - House M.D. | |  | | Charlie Pace (Dominic Monaghan) & Claire Littleton (Emilie de Ravin) - Lost | |  | | Ned (Lee Pace) & Charlotte 'Chuck' Charles (Anna Friel) - Pushing Daisies | |
